Description
Urokinase plasminogen activator surface receptor (U-PAR) is also known as PLAUR, Monocyte activation antigen Mo3, CD antigen CD87.
PLAUR contains three UPAR/Ly6 domains.
U-PAR is expressed in neurons of the rolandic area of the brain (at protein level) and is also expressed in the brain.
PLAUR / CD87 interacts with MRC2, SRPX2 and SORL1.
PLAUR / UPAR acts as a receptor for urokinase plasminogen activator and plays a role in localizing and promoting plasmin formation.
U-PAR mediates the proteolysis-independent signal transduction activation effects of U-PA